Epub 2015 Jan 13. Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). Histopathology of fibroadenoma of the breast. The key to breast pathology is the myoepithelial cell. ; Chen, YY. Complex fibroadenoma with sclerosing adenosis (crowded, Complex fibroadenoma with sclerosing adenosis (crowded glands in a fibrotic stroma) (hematoxylin-eosin; original magnification, MeSH Epithelial component often not compressed - as in fibroadenoma. -->, Richard L Kempson MD Risk appears to be slightly higher in those patients with a positive family history of breast cancer. FOIA radial scar or papilloma) that is identified on imaging, May show enhancement on magnetic resonance imaging (, Associated with 1.5 - 2 times increased risk for subsequent breast cancer (, Risk may be slightly higher for patients with a positive family history of breast cancer (, Indicator of general breast cancer risk rather than direct precursor lesion, 30 year old woman with immature-like usual ductal hyperplasia in a fibroadenoma (, 75 year old woman with malignant phyllodes tumor with liposarcomatous differentiation and intraductal hyperplasia (, Usual ductal hyperplasia within gynecomastia-like changes of the female breast (, Proliferation of cells of luminal and myoepithelial lineages, occasionally with intermixed apocrine cells, Mild variation in cellular and nuclear size and shape, Relatively small ovoid nuclei with frequent elongated or asymmetrically tapered (pear shaped) forms, Lightly granular euchromatic chromatin and small nucleoli, Frequent longitudinal nuclear grooves (coffee bean-like) and occasional nuclear pseudoinclusions, Many examples demonstrate cellular maturation, where the cells shrink as they progress from a basal location to the center of the proliferation, becoming small and nearly pyknotic, Eosinophilic, nonabundant cytoplasm with indistinct cell borders, Cohesive proliferation with haphazard, jumbled cell arrangement or streaming growth pattern, Fenestrated, solid and occasional micropapillary patterns, Irregular slit-like fenestrations are common, especially along periphery, Cells run parallel to the edges of secondary spaces and do not exhibit a polarized orientation (this contrasts with the cells of atypical ductal hyperplasia and ductal carcinoma in situ, which have apical-basal polarity and radially orient their apical poles toward the spaces), Typically focal in a background of conventional pattern usual ductal hyperplasia, Short stubby papillae of roughly uniform height, Cytologic features of usual ductal hyperplasia, Cellular maturation present, with tips of papillae formed by tight knots of mature cells, Larger immature basal hyperplastic cells predominate or are increased beyond their usual 1 - 2 cell layers and are instead several cell layers thick, Most often encountered in fibroepithelial lesions with cellular stroma, Florid usual ductal hyperplasia can rarely demonstrate central necrosis, Typically occurs within a radial scar / complex sclerosing lesion, nipple adenoma or juvenile papillomatosis, Florid usual ductal hyperplasia within radial scars / complex sclerosing lesions can occasionally have more active appearing nuclei with mild nuclear enlargement, Other cytologic and architectural features of usual ductal hyperplasia remain intact, Sample may be moderately to highly cellular, Sheets and cohesive clusters of bland ductal cells with regular spacing and associated myoepithelial cells (, Lack of significant nuclear overlap / crowding, Ductal cell nuclei with finely granular chromatin and inconspicuous small nucleoli, Naked myoepithelial cell nuclei in the background may be present, Activating mutations in the PI3K / AKT / mTOR pathway may play a role in pathogenesis (, Round to oval nuclei with homogeneous, fine and hyperchromatic chromatin; inconspicuous nucleoli; and smooth nuclear contours, Increased amounts of pale eosinophilic to amphophilic cytoplasm with conspicuous cell borders, Cellular polarization around luminal and secondary spaces, Atypical architectural patterns formed by polarized growth (cribriform spaces, Roman arches, trabecular bars, micropapillae), Moderate nuclear enlargement throughout the proliferation, Abnormal chromatin, which may be hyperchromatic, cleared and clumped or coarsely granular, Solid epithelial proliferation showing marked expansion of multiple circumscribed duct spaces (, Thin fibrovascular cores punctuate the proliferation, with cellular palisading around the cores, Myoepithelial cells often sparse or absent along fibrovascular cores, Nuclei may superficially resemble those in usual ductal hyperplasia but demonstrate greater populational uniformity, are slightly larger and have abnormal chromatin, Often positive for neuroendocrine markers (, No change in risk compared to control populations, HMWCK mosaic positive / ER diffusely positive, HMWCK mosaic positive / ER heterogeneously positive. Although no significant difference was noted in patients' age and tumor size between CFA and NCFA, 5 CFA cases (33.3 %) were accompanied by the presence of carcinoma in the same breast or the contralateral breast while no NCFA cases had carcinoma in the breast. 1995 Mar;77(2):127-30. Fibroadenoma is a benign tumor that arises from the epithelium and stroma of terminal duct-lobular unit. Florid usual ductal hyperplasia in radial scar, Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA). Conclusion: Usual ductal hyperplasia is associated with a slight increase in risk (1.5 - 2 times) for subsequent breast cancer. http://radiopaedia.org/articles/complex-fibroadenoma, Lobular intraepithelial neoplasia arising within breast fibroadenoma. sharing sensitive information, make sure youre on a federal Int J Environ Res Public Health. Epub 2021 Jul 12 doi: 10.1371/journal.pone.0253764. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr, Rados MS, Schuyler PA. N Engl J Med. sclerosing adenosis and Complex type; Fibroadenoma; Fine needle aspiration. Excision of breast fibroepithelial lesions: when is it still necessary?-A 10-year review of a regional centre. Mastopathic fibroadenoma of the breast: a pitfall of aspiration cytology. Pathology. Pseudoangiomatous stromal hyperplasia [TI] free full text[sb], WHO Classification of Tumours Editorial Board: Breast Tumours (Medicine), 5th Edition, 2019, Schnitt: Biopsy Interpretation of the Breast (Biopsy Interpretation Series), 3rd Edition, 2017, Stanford University: Pseudoangiomatous Stromal Hyperplasia [Accessed 5 March 2020], Benign myofibroblastic proliferation simulating a vascular lesion, Usually an incidental finding but may produce palpable or mammographic mass, Complex interanastomosing spaces in dense collagenous, keloid-like stroma, Some of these spaces have spindle shaped myofibroblasts at their margins that simulate endothelial cells, Spindle cells are positive for ER, PR and CD34 but negative for other vascular markers, e.g. atypical ductal hyperplasia, atypical lobular hyperplasia) often as a result of spread from an adjacent lesion, Similar structure but with prominent myxoid stromal change composed of abundant pale, blue-gray extracellular matrix material, Cysts > 3 mm, sclerosing adenosis, epithelial microcalcifications or papillary apocrine metaplasia (, Increased epithelial hyperplasia with gynecomastoid-like micropapillary projections, Usual (adult type) fibroadenoma: biphasic population composed of abundant spindle stromal cells and naked nuclei, epithelium arranged in antler horn clusters or fenestrated honeycomb sheets (, Myxoid fibroadenoma: high cellularity with stroma and epithelium embedded in myxoid background (, Cellular variant of fibroadenoma shows higher rates of mutation in. +/-"Stromal overgrowth" = large area where there is a 'loss of glands'. Stanford CA 94305-5342, Relative risk for development of invasive breast carcinoma, , Circumscribed breast mass composed of benign stromal and epithelial cells, Atypical ductal or lobular hyperplasia may be present, Carcinoma, in situ or invasive, may be present, Lacks significant stromal hypercellularity, Elevated stromal mitotic rate, usually >4-5 per 10 hpf, abnormal forms may be found, May contain poorly circumscribed areas of fibrocystic change, Lobules typically present (may be atrophic), Frequent intracanalicular or tubular glandular proliferation. 2013 Jul 12;6:267. doi : 10.1186/1756-0500-6-267 PMID: 23849288 (Free), Histopathology of fibroadenoma of the breast. 8600 Rockville Pike Contact | 2. Methods A retrospective review was performed of patients . 1997 Sep-Oct;42(5):278-87. J Natl Cancer Inst. Richard L Kempson MD. The purpose of this study is to examine the breast cancer risk overall among women with simple fibroadenoma or complex fibroadenoma and to examine the association of complex fibroadenoma with breast cancer through stratification of other breast cancer risks. Dupont WD, Page DL, Parl FF, Vnencak-Jones CL, Plummer WD Jr, Rados MS, Schuyler PA. Stroma is generally more sparse than in conventional fibroadenoma. ADVERTISEMENT: Radiopaedia is free thanks to our supporters and advertisers. Comparative Proteomic Profiling of Secreted Extracellular Vesicles from Breast Fibroadenoma and Malignant Lesions: A Pilot Study. Check for errors and try again. Results: Contributed by Andrey Bychkov, M.D., Ph.D. Fibroadenomatoid changes (sclerosing lobular hyperplasia, fibroadenomatoid mastopathy), Benign biphasic tumor composed of a proliferation of both glandular epithelial and stromal components of the terminal duct lobular unit, Most common breast tumor in adolescent and young women, Benign biphasic tumor comprised of glandular epithelium and specialized interlobular stroma of the terminal ductal lobular unit (, Can show a spectrum of histologic appearances; generally uniform in stromal cellularity and distribution of glandular and stromal elements within a given lesion (an important distinction from phyllodes tumor), Fibroadenomas with hypercellular stroma and prominent intracanalicular pattern can show morphologic overlap with benign phyllodes tumors, especially in needle biopsy specimens, Fibroadenoma, usual type fibroadenoma, adult type fibroadenoma, Most common benign tumor of the female breast, Can occur at any age, median age of 25 years (, Juvenile fibroadenoma generally occurs in younger and adolescent patients < 20 years; reported in children at a very young age (, Complex fibroadenoma reported in older patients with median age between 35 - 47 years (, Increased relative risk (1.5 - 2.0) of subsequent breast cancer; relative risk is higher (3.1) in complex fibroadenomas; no increased risk for juvenile fibroadenoma (, Can occur in axilla accessory breast tissue, Increased risk associated with cyclosporine immunosuppression (, Often presents as painless, firm, mobile, slow growing mass, Usually solitary, can be multiple and bilateral, Usually less than 3 cm in diameter but may grow to large size (, Histologic examination of involved tissue, Sonographically seen usually as a round or oval mass, smooth margins with hypo or isoechoic features (, Can be associated with calcifications, especially in postmenopausal patients, 16 year old girl with 28 cm left breast mass (, 17 year old girl with recurrent juvenile fibroadenoma (, 18 year old woman with mass in axilla accessory breast tissue (, 35 year old woman with left breast mass (, 37 year old woman with increased uptake of breast mass on PET scan (, 44 year old woman with bilateral breast masses (, Management depends on patient risk factors and patient preference, Conservative management with close clinical followup, especially if concordant radiology findings (, Local surgical excision, especially if symptomatic (, If atypia / neoplasia is found within a fibroadenoma, the surgical and systemic therapeutic management is specific and appropriate to the primary atypical / neoplastic lesion, Firm, well circumscribed, ovoid mass with bosselated surface, lobulations bulge above the cut surface, slit-like spaces, May have mucoid or fibrotic appearance; can be calcified, Biphasic tumor, proliferation of both glandular and stromal elements, 2 recognized growth patterns (of no clinical significance, both patterns may occur within a single lesion), Intracanalicular: glands are compressed into linear branching structures by proliferating stroma, Pericanalicular: glands retain open lumens but are separated by expanded stroma, Glandular elements have intact myoepithelial cell layer, Often associated with usual type ductal hyperplasia, apocrine metaplasia, cyst formation or squamous metaplasia, Rare mitotic activity can be observed in the glandular component, has no clinical significance, Generally uniform cellularity within a given lesion, Collagen and bland spindle shaped stromal cells with ovoid or elongated nuclei, Usually no mitotic activity; rare mitotic activity may be present in young or pregnant patients (, Stroma may show myxoid change or hyalinization, Rarely benign heterologous stromal elements (adipose, smooth muscle, osteochondroid metaplasia), Fibroadenomas may be involved by mammary neoplasia (e.g. Webpathology.com: A Collection of Surgical Pathology Images . Accessibility The mediator complex subunit 12 (MED12) gene is the most common gene involved in the pathogenesis of fibroadenoma. Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A. Cureus. FNA diagnosis was retrospectively re-evaluated from FNA reports. Robert V Rouse MD rouse@stanford.edu. Contain proliferative epithelium which outside and inside a fibroadenoma is associated with an increased risk of malignancy. Molecular pathology. Essentials in Bone and Soft-Tissue Pathology - Jasvir S. Khurana 2010-03-10 Essentials in Bone and Soft-Tissue Pathology is a concise and well-illustrated handbook that captures the salient points of the most common problems in bone and soft-tissue . Complex fibroadenomas tend to occur in older patients (median age, 47 years) compared with simple fibroadenomas (median age, 28.5 years). ADVERTISEMENT: Supporters see fewer/no ads, Please Note: You can also scroll through stacks with your mouse wheel or the keyboard arrow keys. font-family: Arial, Helvetica, sans-serif; 2006 Oct;192(4):545-7. doi: 10.1016/j.amjsurg.2006.06.011. Complex fibroadenoma is a sub type of fibroadenoma harbouring one or more of the following features: epithelial calcifications papillary apocrine metaplasia sclerosing adenosis and cysts larger than 3 mm. Site Map Well circumscribed tumor with bulging cut surface, Fibroadenoma with atypical ductal hyperplasia, Sign up for our What's New in Pathology e-newsletter, Copyright PathologyOutlines.com, Inc. Click, 30150 Telegraph Road, Suite 119, Bingham Farms, Michigan 48025 (USA). Tumors of the Mammary Gland, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 7, 1993. However, we cannot answer medical or research questions or give advice. Surgical Pathology Criteria At the time the article was created The Radswiki had no recorded disclosures. Bookshelf Printed from Surgical Pathology Criteria: Stroma compresses ducts into slit-like spaces, Myoepithelial cells and myofibroblasts not prominent, May be hyalinized, especially in older patients, Ducts lined by epithelial and myoepithelial cells, May be seen at least focally in half of cases, "Complex fibroadenoma" has been applied if any of the following are present, Invasive carcinoma is present in adjacent breast in half of patients with in situ carcinoma in a fibroadenoma, Mean age of cases with carcinoma is in 40's, Tumors >500 g or disproportionally large compared to rest of breast, More frequent in young and black patients, Smooth muscle actin typically negative to focal/weak, Complex fibroadenoma (approximately 3 times risk), Atypical ductal hyperplasia (no family history), Atypical ductal hyperplasia, if history of carcinoma in primary relatives, Rosen PP, Oberman HA. phyllodes tumour, sarcoma, pseudoangiomatous . Keywords: A simple fibroadenoma does not raise your risk for breast cancer. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. 2015 Aug;4(4):312-21. doi: 10.3978/j.issn.2227-684X.2015.06.04. PMC Disclaimer. Bethesda, MD 20894, Web Policies Fibroadenoma is the most common benign tumor of the female breast. PMC Systematic review of fibroadenoma as a risk factor for breast cancer. Fibroadenomas may demonstrate estrogen and progesterone sensitivity and may grow during pregnancy. Long-term risk of breast cancer in women with fibroadenoma. In this review, the pathology of the fibroadenoma and phyllodes tumour is revisited, with emphasis on diagnostic and management implications. FNA of CFA can lead to erroneous or indeterminate interpretation, due to proliferative and/or hyperplastic changes of ductal epithelium with or without atypia. ~50% of these tend to be lobular carcinoma in situ (LCIS), ~20% infiltrating lobular carcinoma, ~20%ductal carcinoma in situ (DCIS), and the remaining 10% are infiltrating ductal carcinoma. Arch Pathol Lab Med. May be hyalinized (dark pink) if infarcted. The sections show a lesion with a pale mildly cellular stroma, and bland glandular elements. . Sat-Muoz D, Martnez-Herrera BE, Quiroga-Morales LA, Trujillo-Hernndez B, Gonzlez-Rodrguez JA, Gutirrez-Rodrguez LX, Leal-Corts CA, Portilla-de-Buen E, Rubio-Jurado B, Salazar-Pramo M, Gmez-Snchez E, Delgadillo-Cristerna R, Carrillo-Nuez GG, Nava-Zavala AH, Balderas-Pea LM. Before May be either adult or juvenile type. Benign breast disease and the risk of breast cancer. The site is secure. May be either adult or juvenile type. 2006 Nov 15;98(22):1600-7. doi: 10.1093/jnci/djj439. Giant fibroadenoma. Complex fibroadenoma with sclerosing adenosis (crowded glands in a fibrotic stroma) (hematoxylin-eosin; original magnification 10). epithelial calcifications No calcifications are evident. We consider the term merely descriptive. Epub 2012 Aug 31. Clipboard, Search History, and several other advanced features are temporarily unavailable. Epub 2014 Feb 8. Conclusions: Disclaimer. Federal government websites often end in .gov or .mil. N Engl J Med. View Patrick J Rock's current disclosures, see full revision history and disclosures, invasive ductal carcinoma not otherwise specified, intracystic papillary carcinoma of the breast, breast implant-associated anaplastic large cell lymphoma, columnar alteration with prominent apical snouts and secretions (CAPSS), lobular intraepithelial neoplasia (LIN III), pseudoangiomatous stromal hyperplasia (PASH), pleomorphic microcalcifications within breast, punctate microcalcification within breast, egg shell/rim calcification within breast, lobular calcification within breast tissue, intraductal calcification within breast tissue, skin (dermal) calcification in / around breast tissue, suture calcification within breast tissue, stromal calcification within breast tissue, artifactual calcification from outside the breast, granulomatosis with polyangiitis: breast manifestations, differential diagnosis of dilated ducts on breast imaging, hereditary breast and ovarian cancer syndrome. However, we cannot answer medical or research questions or give advice. This site needs JavaScript to work properly. Our study was to determine the select cytologic features that can accurately distinguish FA from PT. Closely packed uniform tubules, lined by a single layer of epithelial cells and an attenuated myoepithelial cell layer. doi: 10.7759/cureus.12611. Diagnosis in short. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations. Minimal mitotic activity is present (2 mitosis/10 HPF, where 1 HPF ~ 0.2376 mm*mm). HHS Vulnerability Disclosure, Help Bookshelf Can occur at any age, but most patients are young and in their reproductive age group. This website is intended for pathologists and laboratory personnel but not for patients. They fall under the broad group of adenomatous breast lesions. 2021 Jan 10;13(1):e12611. Mori I, Han B, Wang X, Taniguchi E, Nakamura M, Nakamura Y, Bai Y, Kakudo K. Cytopathology. 2001 May;115(5):736-42. doi: 10.1309/F523-FMJV-W886-3J38. official website and that any information you provide is encrypted Department of Pathology. 2021 Jan 10;13(1):e12611. MeSH The luminal cell is epithelial. Diagn Cytopathol. Unauthorized use of these marks is strictly prohibited. Unable to load your collection due to an error, Unable to load your delegates due to an error. papillary apocrine metaplasia incidental finding on histologic examination), Amorphous or pleomorphic clustered microcalcifications; architectural distortion or circumscribed to spiculated mass on mammogram (, Associated with increased mammographic breast density (, Heterogeneous echogenicity, irregular and ill defined mass, focal acoustic shadowing may be seen on ultrasound (, Small (< 1 cm) mass with benign kinetics on MRI (, As a single feature, increased risk of cancer of 1.5 - 2x, as seen with proliferative, 2x higher risk of breast cancer with increased, Does not provide further risk stratification in the presence of other proliferative disease / atypical hyperplasias (, Can mimic malignancy clinically and radiologically, 46 year old woman with sclerosing adenosis with mammogram and cytology mimicking malignancy (, 73 year old woman with sclerosing adenosis and coexisting ductal carcinoma in situ (, 82 year old woman with sclerosing adenosis in sentinel axillary lymph nodes (, Presence of sclerosing adenosis alone in a core biopsy does not require surgical excision, Coexisting atypia will typically prompt surgical consultation, Variable depending on extent of involvement and calcifications, May be indistinguishable from surrounding breast tissue, Multinodular, ill defined, cuts with increased resistance due to fibrosis, Gritty due to frequent calcifications but no chalky yellow white foci or streaks as seen in, Circumscribed to ill defined white, fibrotic mass if nodular adenosis / adenosis tumor, Low power: increase in glandular elements plus stromal fibrosis / sclerosis that distorts and compresses glands, Maintains lobular architecture at low power with rounded and well defined nodules, Centrally is more cellular with distorted and compressed ductules; peripherally has more open or dilated ductules, Often has microcalcifications, due to calcification of entrapped secretions, Preservation of luminal epithelium and peripheral myoepithelium (2 cell layer) with surrounding basement membrane, Myoepithelial cells may vary from being prominent to indistinct on routine H&E staining, Myoepithelial cells are readily apparent via immunohistochemistry, even if difficult to identify on H&E, Rarely penetrates walls of blood vessels or perineural spaces, Epithelium may be involved by proliferative, atypical lesions or in situ carcinoma, If involved by atypia or in situ carcinoma, If florid and overtly non-lobulocentric / (pseudo) infiltrative into fat or stroma, Conspicuous myoepithelial cells with attenuated epithelial cells can appear like stands of single cells and mimic invasive lobular carcinoma, Atypical apocrine metaplasia: nuclear atypia / rare mitosis (, Moderate to markedly cellular, with small to large groups of benign epithelial cells in acinar sheets / cohesive groups / tubules and scattered individual epithelial cells, Also small foci of dense hyalinized stroma (, Tubules may have an angular configuration (, Fibrocystic changes including sclerosing adenosis with microcalcifications, Haphazardly distributed glands (lacks lobulocentric pattern), Lacks myoepithelium but has intact basement membrane, Nodular growth may mimic nodular adenosis / adenosis tumor, Uniform, closely packed tubules (lacks significant distortion by fibrosis), May be difficult to morphologically distinguish from florid sclerosing adenosis with marked distortion and/or involvement by atypia or, More widely spaced tubules with single epithelial layer. National Library of Medicine Percutaneous radiofrequency-assisted excision of fibroadenomas. HHS Vulnerability Disclosure, Help Careers. Carcinoma Breast-Like Giant Complex Fibroadenoma: A Clinical Masquerade. Would you like email updates of new search results? Dehner LP, Hill DA, Deschryver K. Pathology of the breast in children, adolescents, and young adults. Hartmann LC, Sellers TA, Frost MH, Lingle WL, Degnim AC, Ghosh K, Vierkant RA, Maloney SD, Pankratz VS, Hillman DW, Suman VJ, Johnson J, Blake C, Tlsty T, Vachon CM, Melton LJ 3rd, Visscher DW. Kuijper A, Mommers EC, van der Wall E, van Diest PJ. Indian J Plast Surg. Milanese TR, Hartmann LC, Sellers TA, Frost MH, Vierkant RA, Maloney SD, Pankratz VS, Degnim AC, Vachon CM, Reynolds CA, Thompson RA, Melton LJ 3rd, Goode EL, Visscher DW. Fibroadenomas are benign while phyllodes tumor range from benign, indolent neoplasms to malignant tumors capable of distant metastasis. Musio F, Mozingo D, Otchy DP. PMID: 11345838 (Free), Long-term risk of breast cancer in women with fibroadenoma. It is a rare benign rapidly growing breast mass in adolescent females. Complex fibroadenomas are a fibroadenoma subtype harboring one or more complex features. Within this cohort, women who had fibroadenoma were compared to women who did not have fibroadenoma. In particular, these mutations are restricted to the stromal component. We welcome suggestions or questions about using the website. and Debra Zynger, M.D. pathology researchers that rely upon this methodology to perform tissue analysis in research. Accessibility HHS Vulnerability Disclosure, Help Usual ductal hyperplasia[TIAB] free full text[SB], Benign intraductal proliferation of progenitor epithelial cells with varying degrees of solid or fenestrated growth, Streaming growth pattern with fenestrated spaces and lack of cellular polarity, Immunoreactive for high molecular weight cytokeratins, Associated with slight increase in subsequent breast cancer risk (1.5 - 2 times), Also called epithelial hyperplasia, intraductal hyperplasia, hyperplasia of usual type, ductal hyperplasia without atypia, epitheliosis, Most significant finding in 20% of benign breast biopsies (, Proliferation of CK5+ progenitor cells that can differentiate along glandular or myoepithelial lineages; glandular progenitor cells appear to predominate and show intermediate levels of differentiation (, Diagnosis by histologic examination of tissue removed via biopsy or surgical excision, No specific mammographic findings; occasional examples are associated with microcalcifications, Can involve an underlying lesion (e.g. These tumors are usually benign, but they can come back and cause the breast to look abnormal if not totally removed.
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